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Foundation One™

FoundationOne™ includes testing for all classes of alterations in each of the genes listed below.

As a pan-cancer test, FoundationOne™ is designed to interrogate the entire coding sequence of 236 cancer-related genes (3,769 exons) plus 47 introns from 19 genes often rearranged or altered in cancer. These genes are known to be somatically altered in human solid cancers based on recent scientific and clinical literature.

Foundation One™ CURRENT GENE LIST
ABL1 BTK CTNNB1 FGF23 IL7R MLH1 PDGFRA SMO
AKT1 CARD11 DAXX FGF3 INHBA MLL PDGFRB SOCS1
AKT2 CBFB DDR2 FGF4 IRF4 MLL2 PDK1 SOX10
AKT3 CBL DNMT3A FGF6 IRS2 MPL PIK3CA SOX2
ALK CCND1 DOT1L FGFR1 JAK1 MRE11A PIK3CG SPEN
APC CCND2 EGFR FGFR2 JAK2 MSH2 PIK3R1 SPOP
AR CCND3 EMSY (C11orf30)  FGFR3 JAK3 MSH6 PIK3R2 SRC
ARAF CCNE1 EP300 FGFR4 JUN MTOR PPP2R1A STAG2
ARFRP1 CD79A EPHA3 FLT1 KAT6A (MYST3) MUTYH PRDM1 STAT4
ARID1A CD79B EPHA5 FLT3 KDM5A MYC PRKAR1A STK11
ARID2 CDC73 EPHB1 FLT4 KDM5C MYCL1 PRKDC SUFU 
ASXL1 CDH1 ERBB2 FOXL2 KDM6A MYCN PTCH1 TET2
ATM CDK12 ERBB3 GATA1 KDR MYD88 PTEN TGFBR2
ATR CDK4 ERBB4 GATA2 KEAP1 NF1 PTPN11 TNFAIP3
ATRX CDK6 ERG GATA3 KIT NF2 RAD50 TNFRSF14
AURKA CDK8 ESR1 GID4 (C17orf39) KLHL6 NFE2L2 RAD51 TOP1
AURKB CDKN1B EZH2 GNA11 KRAS NFKBIA RAF1 TP53
AXL CDKN2A FAM123B (WTX) GNA13 LRP1B NKX2-1 RARA TSC1
BAP1 CDKN2B FAM46C GNAQ MAP2K1 NOTCH1 RB1 TSC2
BARD1 CDKN2C FANCA GNAS MAP2K2 NOTCH2 RET TSHR
BCL2 CEBPA FANCC GPR124 MAP2K4 NPM1 RICTOR VHL
BCL2L2 CHEK1 FANCD2 GRIN2A MAP3K1 NRAS RNF43 WISP3
BCL6 CHEK2 FANCE GSK3B MCL1 NTRK1 RPTOR WT1
BCOR CIC FANCF HGF MDM2 NTRK2 RUNX1 XPO1
BCORL1 CREBBP FANCG HRAS MDM4 NTRK3 SETD2 ZNF217
BLM CRKL FANCL IDH1 MED12 NUP93 SF3B1 ZNF703
BRAF CRLF2 FBXW7 IDH2 MEF2B PAK3 SMAD2
BRCA1 CSF1R FGF10 IGF1R MEN1 PALB2 SMAD4
BRCA2 CTCF FGF14 IKBKE MET PAX5 SMARCA4
BRIP1 CTNNA1 FGF19 IKZF1 MITF PBRM1 SMARCB1  
SELECT REARRANGEMENTS
ALK BCR BCL2 BRAF EGFR ETV1 ETV4 ETV5
ETV6 EWSR1 MLL MYC NTRK1 PDGFRA RAF1 RARA
RET ROS1 TMPRSS2