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Foundation One®

FoundationOne® includes testing for all classes of alterations in each of the genes listed below.

As a pan-cancer test, FoundationOne® is designed to interrogate the entire coding sequence of 315 cancer-related genes plus select introns from 28 genes often rearranged or altered in cancer. These genes are known to be somatically altered in human solid cancers based on recent scientific and clinical literature.

Current as of August 4, 2014

Foundation One® CURRENT GENE LIST
ABL1 C11orf30 (EMSY) DDR2 FGFR4 IL7R MET PIK3CA SDHD TSHR
ABL2 CARD11 DICER1 FH INHBA MITF PIK3CB SETD2 U2AF1
ACVR1B CBFB DNMT3A FLCN INPP4B MLH1 PIK3CG SF3B1 VEGFA
AKT1 CBL DOT1L FLT1 IRF2 MPL PIK3R1 SLIT2 VHL
AKT2 CCND1 EGFR FLT1 IRF4 MRE11A PIK3R2 SMAD2 WISP3
AKT3 CCND2 EP300 FLT4 IRS2 MSH2 PLCG2 SMAD3 WT1
ALK CCND3 EPHA3 FOXL2 JAK1 MSH6 PMS2 SMAD4 XPO1
AMER1
(FAM123B)
CCNE1 EPHA5 FOXP1 JAK2 MTOR POLD1 SMARCA4 ZBTB2
APC CD274 EPHA7 FRS2 JAK3 MUTYH POLE SMARCB1 ZNF217
AR CD79A EPHB1 FUBP1 JUN MYC PPP2R1A SMO ZNF703
ARAF CD79B ERBB2 GABRA6 KAT6A (MYST3) MYCL (MYCL1) PRDM1 SNCAIP  
ARFRP1 CDC73  ERBB3 GATA1 KDM5A MYCN PREX2 SOCS1  
ARID1A CDH1 ERBB4 GATA2 KDM5C MYD88 PRKAR1A SOX10  
ARID1B CDK12 ERG GATA3 KDM6A NF1 PRKCI SOX2  
ARID2 CDK4 ERRFI1 GATA4 KDR NF2 PRKDC SOX9  
ASXL1 CDK6 ESR1 GATA6 KEAP1 NFE2L2 PRSS8 SPEN  
ATM CDK8 EZH2 GID4
(C17orf39)
KEL NFKBIA PTCH1 SPOP  
ATR CDKN1A FAM46C GLI1 KIT NKX2-1 PTEN SPTA1  
ATRX CDKN1B FANCA GNA11 KLHL6 NOTCH1 PTPN11 SRC  
AURKA CDKN2A FANCC GNA13 KMT2A (MLL) NOTCH2 QKI STAG2  
AURKB CDKN2B FANCD2 GNAQ KMT2C (MLL3) NOTCH3 RAC1 STAT3  
AXIN1 CDKN2C FANCE GNAS KMT2D (MLL2) NPM1 RAD50 STAT4  
AXL CEBPA FANCF GPR124 KRAS NRAS RAD51 STK11  
BAP1 CHD2 FANCG GRIN2A LMO1 NSD1 RAF1 SUFU  
BARD1 CHD4 FANCL GRM3 LRP1B NTRK1 RANBP2 SYK  
BCL2 CHEK1 FAS GSK3B LYN NTRK2 RARA TAF1  
BCL2L1 CHEK2 FAT1 H3F3A LZTR1 NTRK3 RB1 TBX3   
BCL2L2 CIC FBXW7 HGF MAGI2 NUP93 RBM10 TERC   
BCOR CREBBP FGF10 HNF1A MAP2K1 PAK3 RET  TERT
(promoter only)
 
BCORL1 CRKL FGF14 HRAS MAP2K2 PALB2 RICTOR   TET2  
BLM CRLF2 FGF19 HSD3B1 MAP2K4 PARK2 RNF43 TGFBR2  
BRAF CSF1R FGF23 HSP90AA1 MAP3K1 PAX5 ROS1 TNFAIP3  
BRCA1 CTCF FGF3 IDH1 MCL1 PBRM1 RPTOR TNFRSF14  
BRCA2 CTNNA1 FGF4 IDH2 MDM2 PDCD1LG2 RUNX1 TOP1  
BRD4 CTNNB1 FGF6 IGF1R MDM4 PDGFRA RUNX1T1 TOP2A  
BRIP1 CUL3 FGFR1 IGF2 MED12 PDGFRB SDHA TP53  
BTG1 CYLD FGFR2 IKBKE MEF2B PDK1 SDHB TSC1  
BTK DAXX FGFR3 IKZF1 MEN1 PIK3C2B SDHC TSC2  
SELECT REARRANGEMENTS
ALK BRAF BRD4 ETV4 ETV6 KIT MYC NTRK2 RARA TMPRSS2
BCL2 BRCA1 EGFR ETV5 FGFR2 MSH2 NOTCH2 PDGFRA RET  
BCR BRCA2 ETV1 ETV6 FGFR3 MYB NTRK1 RAF1 ROS1  

To obtain gene lists from previous versions of FoundationOne please contact Client Services at client.services@foundationmedicine.com